منابع مشابه
Flexible protein-protein docking: MTgase / G-CSF
Microbial Transglutaminase (MTgase) shows a wide specificity of action in its ability to interact with proteins from different families. Previous experimental data (in collaboration with BIOKER, POLARIS, Pula, Italy) demonstrated that MTGase interacts and transglutaminates the Granulocyte-Colony-StimulatingFactor (GCSF) at residue Q135. In this work this interaction is investigated through the ...
متن کاملProtein Synthesis in Synaptosomal Fractions
A quantitative ultrastructural radioautographic study of in vitro protein synthesis has been carried out in rat synaptosomal fractions incubated with tritiated leucine or a tritiated amino acid mixture. Analysis of grain density distribution demonstrated that presynaptic endings are labeled. 30-50% of the developed grains, representing tritiated amino acids incorporated into proteins, were rela...
متن کاملSerum Lipid and Protein Fractions
Ninety-six patients were observed at intervals for as long as three and one-half years in some cases. In most instances multiple determinations were made during this time using the electrophoretic pattern of the proteins before and after cold ether extraction (McFarlane method), to measure lipid transport. Hyperlipemia usually produced an increased in beta globulin. A varying decrease in albumi...
متن کاملIMPROVEMENT OF hGM-CSF EXPRESSION USING A FUSION SYSTEM BY DIRECTING PROTEIN TO THE PERIPLASMIC SPACE
Bacterial expression systems provide economic and logistic advantages in manufacturing proteins for human therapeutic purposes. However, most such proteins accumulate in insoluble biologicaIIy inactive form when overexpressed in bacterial cells. This is the case while attempting to produce recombinant human granulocyte-macrophage colony stimulating factor (hGM-CSF) in E. coli. In this repor...
متن کاملEtravirine in CSF is highly protein bound.
OBJECTIVES Etravirine has high affinity for plasma drug-binding proteins, such as albumin and α1-acid glycoprotein, which limits the amount of unbound etravirine available to enter the CNS. The objective of this study was to compare total and unbound etravirine concentrations in CSF with plasma concentrations and the in vitro median inhibitory concentration (IC50) for wild-type HIV (0.9 ng/mL)....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMJ
سال: 1965
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5458.421-a